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Per-Arne Svensson
Professor
Institutionen för vårdvetenskap ochViceprefekt
Institutionen för vårdvetenskap ochOm Per-Arne Svensson
Per-Arne Svensson är Professor i Medicinsk vetenskap, Docent i Molekylär Medicin och doktor i Medicin med inriktning mot Endokrinologi.
Forskning Per-Arne forskar inom områdena fetma, diabetes och kardiovaskulär sjukdom. Forskningsfokus är kring molekylära och genetiska mekanismer kring dessa sjukdomar. Han bedriver även klinisk forskning, främst i SOS-studien (en matchad långtidsstudie som studerar effekten av fetmakirurgi). Ett forskningsfokus inom SOS-studien är att studera hur vardaglivet förändras efter fetmakirurgi.
Forskningsgrupp: Swedish Obese subjects (SOS) study group. Populärvetenskaplig beskrivning av forskargruppens viktigaste fynd kan du hitta på https://www.hobs.se/zone/sos-studien/inside/369
Undervisning Huvuddelen av undervisningen sker under Anatomi och Fysiologi kurserna på grundutbildningen för sjuksköterskor och röntgensjuksköterskor.
Nyckelord fetma, fetmakirurgi, diabetes, kardiovaskulär sjukdom, anatomi och fysiologi
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Perceived Body Size in Relation to 10-Year Weight Change in the Swedish Obese Subjects Intervention
Study
Verena Parzer, Magdalena Taube, Bernhard Ludvik, Markku Peltonen, Per-Arne Svensson, Johanna Maria Brix, Kajsa Sjöholm
OBESITY FACTS - 2024 -
Development and validation of an interpretable machine learning-based calculator for predicting 5-year weight trajectories after bariatric surgery: a multinational retrospective cohort SOPHIA
study.
Patrick Saux, Pierre Bauvin, Violeta Raverdy, Julien Teigny, Hélène Verkindt, Tomy Soumphonphakdy, Maxence Debert, Anne Jacobs, Daan Jacobs, Valerie Monpellier, Phong Ching Lee, Chin Hong Lim, Johanna C. Andersson-Assarsson, Carlsson Lena, Per-Arne Svensson, Florence Galtier, Guelareh Dezfoulian, Mihaela Moldovanu, Severine Andrieux, Julien Couster, Marie Lepage, Erminia Lembo, Ornella Verrastro, Maud Robert, Paulina Salminen, Geltrude Mingrone, Ralph Peterli, Ricardo V Cohen, Carlos Zerrweck, David Nocca, Carel W Le Roux, Robert Caiazzo, Philippe Preux, François Pattou
The Lancet. Digital health - 2023 -
Long-term incidence of haematological cancer after bariatric surgery or usual care in the Swedish Obese Subjects study: a prospective cohort
study
Kajsa Sjöholm, Johanna Andersson, Felipe M. Kristensson, Stephan Hjorth, Hege Garelius, Peter Jacobson, Per-Arne Svensson, Sofie Ahlin, Björn Carlsson, Markku Peltonen, Lena M S Carlsson, Magdalena Taube
Lancet Healthy Longevity - 2023 -
Life expectancy after bariatric surgery or usual care in patients with or without baseline type 2 diabetes in Swedish Obese
Subjects.
Lena M S Carlsson, Björn Carlsson, Peter Jacobson, Cecilia Karlsson, Johanna C. Andersson-Assarsson, Felipe Kristensson, Sofie Ahlin, Per-Arne Svensson, Magdalena Taube, Ingmar Näslund, Kristjan Karason, Markku Peltonen, Kajsa Sjöholm
International journal of obesity (2005) - 2023 -
Bariatric surgery, osteoarthritis and arthroplasty of the hip and knee in Swedish Obese Subjects - up to 31 years follow-up of a controlled intervention
study.
L S Lohmander, M Peltonen, Johanna C. Andersson-Assarsson, Cristina Maglio, Kajsa Sjöholm, Magdalena Taube, Peter Jacobson, Per-Arne Svensson, Lena M S Carlsson, Sofie Ahlin
Osteoarthritis and cartilage - 2023 -
Non-alcohol substance use disorder after bariatric surgery in the prospective, controlled Swedish Obese Subjects
study.
Per-Arne Svensson, Markku Peltonen, Johanna C. Andersson-Assarsson, Sofie Ahlin, Petra Brembeck, My Engström, Peter Jacobson, Magdalena Taube, Kajsa Sjöholm, Lena M S Carlsson
Obesity (Silver Spring, Md.) - 2023 -
Seeking lifestyle counselling at primary health care centres: a cross-sectional study in the Swedish
population
Frida Lundin Gurné, Per-Arne Svensson, Ida Björkman, Eva Lidén, Sofie Jakobsson
BMC Primary Care - 2023 -
Evolution of age-related mutation-driven clonal haematopoiesis over 20 years is associated with metabolic dysfunction in
obesity
Johanna C. Andersson-Assarsson, R. C. van Deuren, Felipe M. Kristensson, M. Steehouwer, Kajsa Sjöholm, Per-Arne Svensson, M. Pieterse, C. Gilissen, Magdalena Taube, Peter Jacobson, Rosie Perkins, H. G. Brunner, M. G. Netea, M. Peltonen, Björn Carlsson, A. Hoischen, Lena M S Carlsson
Ebiomedicine - 2023 -
Association of Bariatric Surgery With Cancer Incidence in Patients With Obesity and Diabetes: Long-Term Results From the Swedish Obese Subjects
Study.
Kajsa Sjöholm, Lena M S Carlsson, Per-Arne Svensson, Johanna C. Andersson-Assarsson, Felipe M. Kristensson, Peter Jacobson, Markku Peltonen, Magdalena Taube
Diabetes care - 2022 -
Human adipose tissue gene expression of solute carrier family 19 member 3 (SLC19A3); relation to obesity and
weight-loss
M. J. Pereira, Johanna C. Andersson-Assarsson, Peter Jacobson, P. Kamble, Magdalena Taube, Kajsa Sjöholm, Lena M S Carlsson, Per-Arne Svensson
Obesity Science & Practice - 2022 -
Comparison of the novel WEst coast System for Triage (WEST) with Rapid Emergency Triage and Treatment System (RETTS (c)): an observational pilot
study
S. Habbouche, T. Carlson, D. Johansson, S. Kjaerbeck, M. Malm, Per-Arne Svensson, Lina Holmqvist
International Journal of Emergency Medicine - 2022 -
A SNP in the 5’ flanking region of the SAA1 gene is associated with serum levels of serum amyloid A and cardiovascular risk
factors.
Sofie Ahlin, Maja Löfgren, Magdalena Taube, Johanna C. Andersson-Assarsson, Markku Peltonen, Per-Arne Svensson, Peter Jacobson, Lena M S Carlsson, Kajsa Sjöholm
Translational Medicine Communications - 2022 -
Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin
Resistance
R. A. Jersin, D. S. P. Tallapragada, A. Madsen, L. Skartveit, E. Fjaere, A. McCann, L. Dyer, A. Willems, J. I. Bjune, M. S. Bjune, V. Vage, H. J. Nielsen, H. L. Thorsen, B. G. Nedrebo, C. Busch, V. M. Steen, M. Bluher, Peter Jacobson, Per-Arne Svensson, J. Ferno, M. Ryden, P. Arner, O. Nygard, M. Claussnitzer, S. Ellingsen, L. Madsen, J. V. Sagen, G. Mellgren, S. N. Dankel
Diabetes - 2021 -
Long-term incidence of colorectal cancer after bariatric surgery or usual care in the Swedish Obese Subjects
study.
Magdalena Taube, Markku Peltonen, Kajsa Sjöholm, Richard Palmqvist, Johanna C. Andersson-Assarsson, Peter Jacobson, Per-Arne Svensson, Carlsson Lena
PloS one - 2021 -
Long-term risk of anaemia after bariatric surgery: results from the Swedish Obese Subjects
study
K. Johansson, Per-Arne Svensson, J. Soderling, M. Peltonen, M. Neovius, Lena M S Carlsson, Kajsa Sjöholm
Lancet Diabetes & Endocrinology - 2021 -
Development of a BMI-Assigned Stunkard Scale for the Evaluation of Body Image Perception Based on Data of the SOS Reference
Study.
Verena Parzer, Kajsa Sjöholm, Johanna Maria Brix, Per-Arne Svensson, Bernhard Ludvik, Magdalena Taube
Obesity facts - 2021 -
Adiponectin Associates with Rheumatoid Arthritis Risk in Overweight and Obesity Independently of Other
Adipokines
Yuan Zhang, L. Johansson, Johanna C. Andersson-Assarsson, Magdalena Taube, M. Peltonen, Per-Arne Svensson, C. Herder, Anna Rudin, Lena M S Carlsson, S. Rantapaa-Dahlqvist, Cristina Maglio
Journal of Clinical Medicine - 2021 -
Expansion of mutation-driven haematopoietic clones is associated with insulin resistance and low HDL-cholesterol in individuals with
obesity
Rosanne van Deuren, Johanna Andersson, Felipe M. Kristensson, Marloes Steehouwer, Kajsa Sjöholm, Per-Arne Svensson, Marc Pieterse, Christian Gilissen, Magdalena Taube, Peter Jacobson, Rosie Perkins, Han Brunner, Mihai Netea, Markku Peltonen, Björn Carlsson, Alexander Hoischen, Lena M S Carlsson
bioRxiv - 2021 -
Long-term incidence of hypoglycaemia-related events after bariatric surgery or usual care in the Swedish Obese Subjects study: A register-based
analysis
Kajsa Sjöholm, Peter Jacobson, Magdalena Taube, Per-Arne Svensson, Johanna C. Andersson-Assarsson, Lena M S Carlsson, M. Peltonen
Diabetes Obesity & Metabolism - 2021 -
Prediction of Suicide and Nonfatal Self-harm After Bariatric Surgery: A Risk Score Based on Sociodemographic Factors, Lifestyle Behavior, and Mental Health: A Nonrandomized Controlled
Trial
Hanna Konttinen, Kajsa Sjöholm, Peter Jacobson, Per-Arne Svensson, Carlsson Lena, Markku Peltonen
Annals of surgery - 2021 -
Remission and progression of pre-existing micro- and macroalbuminuria over 15 years after bariatric surgery in Swedish Obese Subjects
study.
Alexander Shulman, Johanna C. Andersson-Assarsson, C D Sjöström, Peter Jacobson, Magdalena Taube, Kajsa Sjöholm, C W le Roux, M Peltonen, Carlsson Lena, Per-Arne Svensson
International journal of obesity - 2021 -
Nursing students' experiences of a pedagogical transition from campus learning to distance learning using digital
tools.
Ulrica Langegård, Kiana Kiani, Susanne Nielsen, Per-Arne Svensson
BMC nursing - 2021 -
9p21.3 Coronary Artery Disease Locus Identifies Patients With Treatment Benefit From Bariatric Surgery in the Nonrandomized Prospective Controlled Swedish Obese Subjects
Study.
Peter Jacobson, Markku Peltonen, Per-Arne Svensson, Magdalena Taube, Johanna C. Andersson-Assarsson, Kajsa Sjöholm, Claude Bouchard, Björn Carlsson, Lena M S Carlsson
Circulation. Genomic and precision medicine - 2020 -
Comparison of Preoperative Remission Scores and Diabetes Duration Alone as Predictors of Durable Type 2 Diabetes Remission and Risk of Diabetes Complications After Bariatric Surgery: A Post Hoc Analysis of Participants From the Swedish Obese Subjects
Study.
Kajsa Sjöholm, Lena M S Carlsson, Magdalena Taube, Carel W le Roux, Per-Arne Svensson, Markku Peltonen
Diabetes care - 2020 -
Evaluation of Prediction Models for Type 2 Diabetes Relapse After Post-bariatric Surgery Remission: a Post hoc Analysis of 15-Year Follow-up Data from the Swedish Obese Subjects (SOS)
Study.
Kajsa Sjöholm, Per-Arne Svensson, Magdalena Taube, Peter Jacobson, Johanna C. Andersson-Assarsson, Carlsson Lena, Markku Peltonen
Obesity surgery - 2020 -
Effects of Bariatric Surgery in Early- and Adult-Onset Obesity in the Prospective Controlled Swedish Obese Subjects
Study.
Felipe M. Kristensson, Johanna C. Andersson-Assarsson, Per-Arne Svensson, Björn Carlsson, Markku Peltonen, Lena M S Carlsson
Diabetes care - 2020 -
Bariatric surgery and the incidence of rheumatoid arthritis - a Swedish Obese Subjects
study.
Cristina Maglio, Yuan Zhang, Markku Peltonen, Johanna C. Andersson-Assarsson, Per-Arne Svensson, Christian Herder, Anna Rudin, Lena M S Carlsson
Rheumatology - 2020 -
Fracture risk after three bariatric surgery procedures in Swedish obese subjects: up to 26 years follow-up of a controlled intervention
study.
Sofie Ahlin, M Peltonen, Kajsa Sjöholm, Åsa Anveden, Peter Jacobson, Johanna C. Andersson-Assarsson, Magdalena Taube, I Larsson, L S Lohmander, I Näslund, Per-Arne Svensson, Lena M S Carlsson
Journal of internal medicine - 2020 -
Elevated adiponectin predicts the development of rheumatoid arthritis in subjects with
obesity
Y Zhang, M. Peltonen, Johanna C. Andersson-Assarsson, Per-Arne Svensson, C. Herder, Anna Rudin, Lena M S Carlsson, Cristina Maglio
Scandinavian Journal of Rheumatology - 2020 -
Association of Bariatric Surgery With Skin Cancer Incidence in Adults With Obesity: A Nonrandomized Controlled
Trial.
Magdalena Taube, Markku Peltonen, Kajsa Sjöholm, Åsa Anveden, Johanna C. Andersson-Assarsson, Peter Jacobson, Per-Arne Svensson, Martin O. Bergö, Carlsson Lena
JAMA dermatology - 2020 -
3-Hydroxyisobutyrate, A Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte
Metabolism
M. S. Nilsen, R. A. Jersin, A. Ulvik, A. Madsen, A. McCann, Per-Arne Svensson, M. K. Svensson, B. G. Nedrebo, O. A. Gudbrandsen, G. S. Tell, C. R. Kahn, P. M. Ueland, G. Mellgren, S. N. Dankel
Diabetes - 2020 -
Reoperations After Bariatric Surgery in 26 Years of Follow-up of the Swedish Obese Subjects
Study.
Stephan Hjorth, Ingmar Näslund, Johanna C. Andersson-Assarsson, Per-Arne Svensson, Peter Jacobson, Markku Peltonen, Lena M S Carlsson
JAMA surgery - 2019 -
Expression of GHR and Downstream Signaling Genes in Human Adipose Tissue-Relation to Obesity and Weight
Change.
Camilla A M Glad, Per-Arne Svensson, Fredrik H Nystrom, Peter Jacobson, Lena M S Carlsson, Gudmundur Johannsson, Johanna C. Andersson-Assarsson
The Journal of clinical endocrinology and metabolism - 2019 -
Long-term incidence of serious fall-related injuries after bariatric surgery in Swedish obese
subjects.
Lena M S Carlsson, Kajsa Sjöholm, Sofie Ahlin, Peter Jacobson, Johanna C. Andersson-Assarsson, Linda Karlsson-Lindahl, Cristina Maglio, Cecilia Karlsson, Stephan Hjorth, Magdalena Taube, Björn Carlsson, Per-Arne Svensson, Markku Peltonen
International journal of obesity (2005) - 2019 -
Self-Reported Weight-Loss Methods and Weight Change: Ten-Year Analysis in the Swedish Obese Subjects Study Control
Group
Edit Zenténius, Johanna C. Andersson-Assarsson, Lena M S Carlsson, Per-Arne Svensson, Ingrid Larsson
Obesity - 2018 -
Associations of Bariatric Surgery With Changes in Interpersonal Relationship Status: Results From 2 Swedish Cohort
Studies.
Gustaf Bruze, Tobias E. Holmin, Markku Peltonen, Johan Ottosson, Kajsa Sjöholm, Ingmar Näslund, Martin Neovius, Lena M S Carlsson, Per-Arne Svensson
JAMA surgery - 2018 -
Incidence of end-stage renal disease following bariatric surgery in the Swedish Obese Subjects
Study.
Alexander Shulman, Markku Peltonen, C D Sjöström, Johanna C. Andersson-Assarsson, Magdalena Taube, Kajsa Sjöholm, Carel W le Roux, Lena M S Carlsson, Per-Arne Svensson
International journal of obesity - 2018 -
Iodine Status After Bariatric Surgery-a Prospective 10-Year Report from the Swedish Obese Subjects (SOS)
Study.
Sofia Manousou, Lena M S Carlsson, Robert Eggertsen, Lena Hulthén, Peter Jacobson, Kerstin Landin-Wilhelmsen, Penelope Trimpou, Per-Arne Svensson, Helena Filipsson Nyström
Obesity surgery - 2018 -
Lysyl oxidase and adipose tissue
dysfunction
E. Pastel, E. Price, Kajsa Sjöholm, L. J. McCulloch, N. Rittig, N. Liversedge, B. Knight, N. Moller, Per-Arne Svensson, K. Kos
Metabolism - Clinical and Experimental - 2018 -
Mechanisms in endocrinology: Clinical and pharmacogenetic aspects of the growth hormone receptor
polymorphism
C. L. Boguszewski, E. J. L. Barbosa, Per-Arne Svensson, Gudmundur Johannsson, Camilla A M Glad
European Journal of Endocrinology - 2017 -
Long-term incidence of microvascular disease after bariatric surgery or usual care in patients with obesity, stratified by baseline glycaemic status: a post-hoc analysis of participants from the Swedish Obese Subjects
study.
Lena M S Carlsson, Kajsa Sjöholm, Cecilia Karlsson, Peter Jacobson, Johanna C. Andersson-Assarsson, Per-Arne Svensson, Ingrid Larsson, Stephan Hjorth, Martin Neovius, Magdalena Taube, Björn Carlsson, Markku Peltonen
The lancet. Diabetes & endocrinology - 2017 -
Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic
review.
Petros C Dinas, Ian M Lahart, James A Timmons, Per-Arne Svensson, Yiannis Koutedakis, Andreas D Flouris, George S Metsios
F1000Research - 2017 -
Long-term incidence of female-specific cancer after bariatric surgery or usual care in the Swedish Obese Subjects
Study
Åsa Anveden, Magdalena Taube, M. Peltonen, Peter Jacobson, Johanna C. Andersson-Assarsson, Kajsa Sjöholm, Per-Arne Svensson, Lena M S Carlsson
Gynecologic Oncology - 2017 -
Normalization of qPCR in platelets - YWHAE a potential genericreference
gene
Karin Mossberg, Per-Arne Svensson, O. Gidlof, D. Erlinge, Sverker Jern, Helén Brogren
Platelets - 2016 -
Microdialysis and proteomics of subcutaneous interstitial fluid reveals increased galectin-1 in type 2 diabetes
patients
Emanuel Fryk, Jeanna Perman Sundelin, Lena Strindberg, Maria J Pereira, M. Federici, N. Marx, Helena Filipsson Nyström, M. Schmelz, Per-Arne Svensson, Jan W Eriksson, Jan Borén, Per-Anders Jansson
Metabolism-Clinical and Experimental - 2016 -
Chronic L-menthol-induced browning of white adipose tissue hypothesis: A putative therapeutic regime for combating obesity and improving metabolic
health
P. Sakellariou, A. Valente, A. E. Carrillo, G. S. Metsios, L. Nadolnik, A. Z. Jamurtas, Y. Koutedakis, C. Boguszewski, C. M. B. Andrade, Per-Arne Svensson, N. H. Kawashita, A. D. Flouris
Medical Hypotheses - 2016 -
The GH receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general
population.
Camilla A M Glad, Lena M S Carlsson, Olle Melander, Peter Almgren, Lars Sjöström, Staffan Nilsson, Ingrid Larsson, Per-Arne Svensson, Gudmundur Johannsson
European journal of endocrinology / European Federation of Endocrine Societies - 2015 -
Evaluation of reference genes for gene expression studies in human brown adipose
tissue.
Magdalena Taube, Johanna C. Andersson-Assarsson, Kristin Lindberg, Maria J Pereira, Markus Gäbel, Maria K Svensson, Jan W Eriksson, Per-Arne Svensson
Adipocyte - 2015 -
Bacterial contamination of suction catheter tips during aortic valve replacement surgery: a prospective observational cohort
study.
Johanna Larsson, Sofia Sutherland, Åsa Söderström, Christine Roman-Emanuel, Anders Jeppsson, Elisabeth Hansson-Olofsson, Per-Arne Svensson
Patient safety in surgery - 2015 -
FTO Obesity Variant Circuitry and Adipocyte Browning in
Humans
M. Claussnitzer, S. N. Dankel, K. H. Kim, G. Quon, W. Meuleman, C. Haugen, V. Glunk, I. S. Sousa, J. L. Beaudry, V. Puviindran, N. A. Abdennur, J. Liu, Per-Arne Svensson, Y. H. Hsu, D. J. Drucker, G. Mellgren, C. C. Hui, H. Hauner, M. Kellis
New England Journal of Medicine - 2015 -
BMP4 and BMP antagonists regulate human white and beige
adipogenesis.
Birgit Gustafson, Ann Hammarstedt, Shahram Hedjazifar, Jenny M Hoffmann, Per-Arne Svensson, Joseph Grimsby, Cristina Rondinone, Ulf Smith
Diabetes - 2015 -
Thermogenic Activity of UCP1 in Human White Fat-Derived Beige
Adipocytes.
Stefano Bartesaghi, Stefan Hallen, Li Huang, Per-Arne Svensson, Remi A Momo, Simonetta Wallin, Eva K Carlsson, Anna Forslöw, Patrick Seale, Xiao-Rong Peng
Molecular endocrinology (Baltimore, Md.) - 2015 -
The incidence of albuminuria after bariatric surgery and usual care in swedish obese subjects (SOS): a prospective controlled intervention
trial.
Lena M S Carlsson, Stefano Romeo, Peter Jacobson, Maria Antonella Burza, Cristina Maglio, Kajsa Sjöholm, Per-Arne Svensson, Börje Haraldsson, Markku Peltonen, Lars Sjöström
International Journal of Obesity - 2015 -
Extracellular water and blood pressure in adults with growth hormone (GH) deficiency: a genotype-phenotype association
study.
Edna J L Barbosa, Camilla A M Glad, Anna G Nilsson, Niklas Bosaeus, Helena Filipsson Nyström, Per-Arne Svensson, Bengt-Åke Bengtsson, Staffan Nilsson, Ingvar Bosaeus, Cesar Luiz Boguszewski, Gudmundur Johannsson
PloS one - 2014 -
Association of Bariatric Surgery With Long-term Remission of Type 2 Diabetes and With Microvascular and Macrovascular
Complications
Lars Sjöström, Markku Peltonen, Peter Jacobson, Sofie Ahlin, Johanna C. Andersson-Assarsson, Åsa Anveden, Bouchard Claude, Björn Carlsson, Kristjan Karason, Hans Lönroth, Ingmar Näslund, Elisabeth Sjöström, Magdalena Taube, Hans Wedel, Per-Arne Svensson, Kajsa Sjöholm, Lena M S Carlsson
Journal of the American Medical Association - 2014 -
Adiponectin and bariatric surgery: Associations with diabetes and cardiovascular disease in the Swedish obese subjects
study
C. Herder, Markku Peltonen, Per-Arne Svensson, M. Carstensen, Peter Jacobson, M. Roden, Lars Sjöström, Lena M S Carlsson
Diabetes Care - 2014 -
SNPs within the GH-signaling pathway are associated with the early IGF1 response to GH replacement therapy in GHD
adults.
Camilla A M Glad, Edna J L Barbosa, Helena Filipsson Nyström, Lena M S Carlsson, Staffan Nilsson, Anna G Nilsson, Per-Arne Svensson, Gudmundur Johannsson
European journal of endocrinology / European Federation of Endocrine Societies - 2014 -
CETP TaqIB genotype modifies the association between alcohol and coronary heart disease: The INTERGENE case-control
study
Kirsten Mehlig, Elisabeth Strandhagen, Per-Arne Svensson, Annika Rosengren, Kjell Torén, Dag Thelle, Lauren Lissner
Alcohol - 2014 -
FKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin
resistance
M.J. Pereira, J. Palming, M.K. Svensson, M. Rizell, J.A. Dalenbäck, M. Hammar, T. Fall, C.O. Sidibeh, Per-Arne Svensson, J.W. Eriksson
Metabolism: Clinical and Experimental - 2014 -
Characterization of brown adipose tissue in the human perirenal
depot.
Per-Arne Svensson, Kristin Lindberg, Jenny M Hoffmann, Magdalena Taube, Maria J Pereira, Tala Mohsen-Kanson, Anne-Laure Hafner, Magnus Rizell, Jenny Palming, Christian Dani, Maria K Svensson
Obesity - 2014 -
Differentiation of Human Induced Pluripotent Stem Cells into Brown and White Adipocytes: Role of
Pax3
T. Mohsen-Kanson, A. L. Hafner, B. Wdziekonski, Y. Takashima, P. Villageois, A. Carriere, Maria Svensson, C. Bagnis, B. Chignon-Sicard, Per-Arne Svensson, L. Casteilla, A. Smith, C. Dani
Stem Cells - 2014 -
CDKN2B expression and subcutaneous adipose tissue expandability: Possible influence of the 9p21 atherosclerosis
locus
Per-Arne Svensson, Björn Wahlstrand, Maja Olsson, P. Froguel, M. Falchi, R. N. Bergman, P. G. McTernan, Thomas Hedner, Lena M S Carlsson, Peter Jacobson
Biochemical and Biophysical Research Communications - 2014 -
Adipose Tissue-Derived Human Serum Amyloid A Does Not Affect Atherosclerotic Lesion Area in hSAA(+/) (-/)ApoE(-/-)
Mice
Sofie Ahlin, Maja Olsson, Anna S K Wilhelmson, Kristina Skålen, Jan Borén, Lena M S Carlsson, Per-Arne Svensson, Kajsa Sjöholm
Plos One - 2014 -
Long-Term Effect of Bariatric Surgery on Liver Enzymes in the Swedish Obese Subjects (SOS)
Study
Maria Antonella Burza, Stefano Romeo, A. Kotronen, Per-Arne Svensson, Kajsa Sjöholm, Jarl S Torgerson, Anna-Karin Lindroos, Lars Sjöström, Lena M S Carlsson, M. Peltonen
Plos One - 2013 -
Alcohol consumption and alcohol problems after bariatric surgery in the swedish obese subjects
study.
Per-Arne Svensson, Åsa Anveden, Stefano Romeo, Markku Peltonen, Sofie Ahlin, Maria Antonella Burza, Björn W. Karlson, Peter Jacobson, Anna-Karin Lindroos, Hans Lönroth, Cristina Maglio, Ingmar Näslund, Kajsa Sjöholm, Hans Wedel, Bo Söderpalm, Lars Sjöström, Lena M S Carlsson
Obesity (Silver Spring, Md.) - 2013 -
The IRS1 rs2943641 Variant and Risk of Future Cancer Among Morbidly Obese
Individuals.
Cristina Maglio, Ulrika Ericson, Maria Antonella Burza, Rosellina Margherita Mancina, Carlo Pirazzi, Johanna C. Andersson-Assarsson, Kajsa Sjöholm, Marco Giorgio Baroni, Per-Arne Svensson, Tiziana Montalcini, Arturo Pujia, Lars Sjöström, Olov Wiklund, Lena M S Carlsson, Jan Borén, Marju Orho-Melander, Stefano Romeo
The Journal of clinical endocrinology and metabolism - 2013 -
Adipose Tissue Resting Energy Expenditure and Expression of Genes Involved in Mitochondrial Function Are Higher in Women than in
Men.
Intawat Nookaew, Per-Arne Svensson, Peter Jacobson, Margareta Jernås, Magdalena Taube, Ingrid Larsson, Johanna C. Andersson-Assarsson, Lars Sjöström, Philippe Froguel, Andrew Walley, Jens B. Nielsen, Lena M S Carlsson
The Journal of clinical endocrinology and metabolism - 2013 -
Macrophage Gene Expression in Adipose Tissue is Associated with Insulin Sensitivity and Serum Lipid Levels Independent of
Obesity.
Sofie Ahlin, Kajsa Sjöholm, Peter Jacobson, Johanna C. Andersson-Assarsson, A Walley, J Tordjman, C Poitou, E Prifti, Per-Anders Jansson, Jan Borén, Lars Sjöström, P Froguel, R N Bergman, Lena M S Carlsson, Bob Olsson, Per-Arne Svensson
Obesity (Silver Spring, Md.) - 2013 -
Evaluation of current eligibility criteria for bariatric surgery: diabetes prevention and risk factor changes in the Swedish obese subjects (SOS)
study.
Kajsa Sjöholm, Åsa Anveden, Markku Peltonen, Peter Jacobson, Stefano Romeo, Per-Arne Svensson, Lars Sjöström, Lena M S Carlsson
Diabetes care - 2013 -
No Evidence for a Role of Adipose Tissue-Derived Serum Amyloid A in the Development of Insulin Resistance or Obesity-Related Inflammation in hSAA1(+/)- Transgenic
Mice
Sofie Ahlin, Maja Olsson, Bob Olsson, Per-Arne Svensson, Kajsa Sjöholm
Plos One - 2013 -
The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity,Weight loss and resting metabolic
rate
Per-Arne Svensson, Maja Olsson, Johanna C. Andersson-Assarsson, Magdalena Taube, Maria J Pereira, P. Froguel, Peter Jacobson
Biochemical and Biophysical Research Communications - BBRC - 2013 -
Bariatric surgery and prevention of type 2 diabetes in Swedish obese
subjects.
Lena M S Carlsson, Markku Peltonen, Sofie Ahlin, Åsa Anveden, Claude Bouchard, Björn Carlsson, Peter Jacobson, Hans Lönroth, Cristina Maglio, Ingmar Näslund, Carlo Pirazzi, Stefano Romeo, Kajsa Sjöholm, Elisabeth Sjöström, Hans Wedel, Per-Arne Svensson, Lars Sjöström
The New England journal of medicine - 2012 -
Genotypes associated with lipid metabolism contribute to differences in serum lipid profile of GH-deficient adults before and after GH replacement
therapy.
Edna J L Barbosa, Camilla A M Glad, Anna G Nilsson, Helena Filipsson Nyström, Galina Götherström, Per-Arne Svensson, Isabela Vinotti, Bengt-Åke Bengtsson, Staffan Nilsson, Cesar Luiz Boguszewski, Gudmundur Johannsson
European journal of endocrinology / European Federation of Endocrine Societies - 2012 -
Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator
expression
Pia Larsson, Erik Ulfhammer, Mia Magnusson, Niklas Bergh, S. Lunke, A. El-Osta, R. L. Medcalf, Per-Arne Svensson, Lena Karlsson, Sverker Jern
PloS one - 2012 -
Bariatric surgery and long-term cardiovascular
events.
Lars Sjöström, Markku Peltonen, Peter Jacobson, Carl David Sjöström, Kristjan Karason, Hans Wedel, Sofie Ahlin, Åsa Anveden, Calle Bengtsson, Gerd Bergmark, Claude Bouchard, Björn Carlsson, Sven Dahlgren, Jan Karlsson, Anna-Karin Lindroos, Hans Lönroth, Kristina Narbro, Ingmar Näslund, Torsten Olbers, Per-Arne Svensson, Lena M S Carlsson
JAMA : the journal of the American Medical Association - 2012 -
ITIH-5 Expression in Human Adipose Tissue Is Increased in
Obesity.
Åsa Anveden, Kajsa Sjöholm, Peter Jacobson, Vilborg Palsdottir, Andrew J Walley, Philippe Froguel, Nasser Al-Daghri, Lars Sjöström, Lena M S Carlsson, Per-Arne Svensson
Obesity - 2012 -
PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese
individuals
Maria Antonella Burza, Carlo Pirazzi, Cristina Maglio, Kajsa Sjöholm, Rosellina Margherita Mancina, Per-Arne Svensson, Peter Jacobson, Martin Adiels, M. G. Baroni, Jan Borén, S. G. Corradini, T. Montalcini, Lars Sjöström, Lena M S Carlsson, Stefano Romeo
Digestive and Liver Disease - 2012 -
Paradoxical Lower Serum Triglyceride Levels and Higher Type 2 Diabetes Mellitus Susceptibility in Obese Individuals with the PNPLA3 148M
Variant
C. N. A. Palmer, Cristina Maglio, Carlo Pirazzi, Maria Antonella Burza, Martin Adiels, L. Burch, L. A. Donnelly, H. Colhoun, A. S. Doney, J. F. Dillon, E. R. Pearson, M. McCarthy, A. T. Hattersley, T. Frayling, A. D. Morris, Markku Peltonen, Per-Arne Svensson, Peter Jacobson, Jan Borén, Lars Sjöström, Lena M S Carlsson, Stefano Romeo
PLoS ONE - 2012 -
Cardiovascular Events After Bariatric Surgery in Obese Subjects With Type 2
Diabetes
Stefano Romeo, Cristina Maglio, Maria Antonella Burza, Carlo Pirazzi, Kajsa Sjöholm, Peter Jacobson, Per-Arne Svensson, M. Peltonen, Lars Sjöström, Lena M S Carlsson
Diabetes Care - 2012 -
Peripheral administration of bovine GH regulates the expression of cerebrocortical beta-globin, GABAB receptor 1, and the Lissencephaly-1 protein (LIS-1) in adult hypophysectomized
rats.
Marion Walser, Anna Hansén, Per-Arne Svensson, Margareta Jernås, Jan Oscarsson, Jörgen Isgaard, N David Åberg
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 2011 -
Gene expression in human brown adipose
tissue.
Per-Arne Svensson, Margareta Jernås, Kajsa Sjöholm, Jenny M Hoffmann, Bengt E Nilsson, Magnus Hansson, Lena M S Carlsson
International journal of molecular medicine - 2011 -
Identification of Adipocyte Genes Regulated by Caloric
Intake.
Niclas Franck, Anders Gummesson, Margareta Jernås, Camilla A M Glad, Per-Arne Svensson, Gilles Guillot, Mats Rudemo, Fredrik H Nyström, Lena M S Carlsson, Bob Olsson
The Journal of clinical endocrinology and metabolism - 2011 -
Establishment of a transgenic mouse model specifically expressing human serum amyloid a in adipose
tissue.
Maja Olsson, Sofie Ahlin, Bob Olsson, Per-Arne Svensson, Marcus Ståhlman, Jan Borén, Lena M S Carlsson, Kajsa Sjöholm
PloS one - 2011 -
Rapid and high throughput genotyping of the growth hormone receptor exon 3 deleted/full-length polymorphism using a
tagSNP.
Camilla A M Glad, Gudmundur Johannsson, Lena M S Carlsson, Per-Arne Svensson
Growth hormone & IGF research - 2010 -
Activin B inhibits lipolysis in 3T3-L1
adipocytes
Björn Magnusson, Per-Arne Svensson, Lena M S Carlsson, Kajsa Sjöholm
Biochemical and biophysical research communications - 2010 -
Changes in human adipose tissue gene expression during diet-induced weight
loss.
Per-Arne Svensson, Anders Gummesson, Lena M S Carlsson, Kajsa Sjöholm
World review of nutrition and dietetics - 2010 -
Expression of chemokine (C-C motif) ligand 18 in human macrophages and atherosclerotic
plaques
Daniel Hägg, Fredrik J. Olson, Josefin Kjelldahl, Margareta Jernås, Dag Thelle, Lena M S Carlsson, Björn Fagerberg, Per-Arne Svensson
Atherosclerosis - 2009 -
ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic
disease.
Lena M S Carlsson, Peter Jacobson, Andrew Walley, Philippe Froguel, Lars Sjöström, Per-Arne Svensson, Kajsa Sjöholm
Biochemical and biophysical research communications - 2009 -
Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight
loss.
Atsuhito Saiki, Maja Olsson, Margareta Jernås, Anders Gummesson, Philip G McTernan, Johanna Andersson, Peter Jacobson, Kajsa Sjöholm, Bob Olsson, Shigeo Yamamura, Andrew Walley, Philippe Froguel, Björn Carlsson, Lars Sjöström, Per-Arne Svensson, Lena M S Carlsson
The Journal of clinical endocrinology and metabolism - 2009 -
Regulation of human aldoketoreductase 1C3 (AKR1C3) gene expression in the adipose
tissue.
Per-Arne Svensson, Britt G. Gabrielsson, Margareta Jernås, Anders Gummesson, Kajsa Sjöholm
Cellular & Molecular Biology Letters - 2008 -
Urokinase-type plasminogen activator receptor is associated with macrophages and plaque rupture in symptomatic carotid
atherosclerosis.
Per-Arne Svensson, Fredrik J. Olson, Daniel Hägg, Mikael Ryndel, Olov Wiklund, Lars Karlström, Johannes Hulthe, Lena M S Carlsson, Björn Fagerberg
International journal of molecular medicine - 2008 -
Expression profiling of macrophages from subjects with atherosclerosis to identify novel susceptibility
genes.
Daniel Hägg, Margareta Jernås, Olov Wiklund, Dag Thelle, Björn Fagerberg, Per Eriksson, Anders Hamsten, Bob Olsson, Björn Carlsson, Lena M S Carlsson, Per-Arne Svensson
International journal of molecular medicine - 2008 -
Cell death-inducing DFF45-like effector C is reduced by caloric restriction and regulates adipocyte lipid
metabolism.
Björn Magnusson, Anders Gummesson, Camilla A M Glad, Julia H Goedecke, Margareta Jernås, Ted Lystig, Björn Carlsson, Björn Fagerberg, Lena M S Carlsson, Per-Arne Svensson
Metabolism: clinical and experimental - 2008 -
Relations of Adipose Tissue Cell Death-Inducing DFFA-like Effector A Gene Expression to Basal Metabolic Rate, Energy Restriction and Obesity: Population-based and Dietary Intervention
Studies.
Anders Gummesson, Margareta Jernås, Per-Arne Svensson, Ingrid Larsson, Camilla A M Glad, Erik Schéle, Lena Gripeteg, Kajsa Sjöholm, Ted Lystig, Lars Sjöström, Björn Carlsson, Björn Fagerberg, Lena M S Carlsson
Journal of Clinical Endocrinology and Metabolism - 2007 -
Augmented levels of CD44 in macrophages from atherosclerotic subjects: a possible IL-6-CD44 feedback
loop?
Daniel Hägg, Sara Sjöberg, Lillemor Mattsson Hultén, Björn Fagerberg, Olov Wiklund, Annika Rosengren, Lena M S Carlsson, Jan Borén, Per-Arne Svensson, Alexandra Krettek
Atherosclerosis - 2007 -
Separation of human adipocytes by size: hypertrophic fat cells display distinct gene
expression
Margareta Jernås, Jenny Palming, Kajsa Sjöholm, Eva Jennische, Per-Arne Svensson, Britt G. Gabrielsson, Max Levin, Anders Sjögren, Mats Rudemo, Ted Lystig, Björn Carlsson, Lena M S Carlsson, Malin Lönn
The FASEB Journal - 2006 -
Evaluation of CXCL9 and CXCL10 as circulating biomarkers of human cardiac allograft
rejection.
Kristjan Karason, Margareta Jernås, Daniel Hägg, Per-Arne Svensson
BMC Cardiovascular Disorders - 2006 -
Hypoxia converts human macrophages into triglyceride-loaded foam
cells.
Pontus Boström, Björn Magnusson, Per-Arne Svensson, Olov Wiklund, Jan Borén, Lena M S Carlsson, Marcus Ståhlman, Sven-Olof Olofsson, Lillemor Mattsson Hultén
Arteriosclerosis, thrombosis, and vascular biology - 2006 -
Oxidized LDL induces a coordinated up-regulation of the glutathione and thioredoxin systems in human
macrophages.
Daniel Hägg, Mikael C. O. Englund, Margareta Jernås, Caroline Schmidt, Olov Wiklund, Lillemor Mattsson Hultén, Bertil Ohlsson, Lena M S Carlsson, Björn Carlsson, Per-Arne Svensson
Atherosclerosis - 2006 -
Increased expression of aquaporin 3 in atopic
eczema.
Maja Olsson, Ann Broberg, Margareta Jernås, Lena M S Carlsson, Mats Rudemo, Mark Suurküla, Per-Arne Svensson, Mikael Benson
Allergy - 2006 -
Major role of HSP70 as a paracrine inducer of cytokine production in human oxidized LDL treated
macrophages.
Per-Arne Svensson, Alexzander Asea, Mikael C. O. Englund, Maria A Bausero, Margareta Jernås, Olov Wiklund, Bertil Ohlsson, Lena M S Carlsson, Björn Carlsson
Atherosclerosis - 2006 -
Regulation and splicing of scavenger receptor class B type I in human macrophages and atherosclerotic
plaques
Per-Arne Svensson, Mikael C. O. Englund, Magnus S C Snäckestrand, Daniel Hägg, Bertil Ohlsson, V. Stemme, Lillemor Mattsson Hultén, Dag Thelle, Björn Fagerberg, Olov Wiklund, Lena M S Carlsson, Björn Carlsson
BMC Cardiovasc Disord - 2005 -
Chromatic interaction between egg pigmentation and skin chromatophores in the nuptial coloration of female two-spotted
gobies
P. A. Svensson, Elisabet Forsgren, T. Amundsen, Helen Nilsson Sköld
Journal of Experimental Biology - 2005 -
Gene expression profile and aortic vessel distensibility in voluntarily exercised spontaneously hypertensive rats: potential role of heat shock
proteins
Ulrika Hägg Samuelsson, Maria E Johansson, Julia Grönros, Andrew Stuart Naylor, Ingibjörg H Jonsdottir, Göran Bergström, Per-Arne Svensson, Li-Ming Gan
Physiol Genomics - 2005 -
A microarray search for genes predominantly expressed in human omental adipocytes: adipose tissue as a major production site of serum amyloid
A.
Kajsa Sjöholm, Jenny Palming, Louise Olofsson, Anders Gummesson, Per-Arne Svensson, Ted Lystig, Eva Jennische, John Brandberg, Jarl S Torgerson, Björn Carlsson, Lena M S Carlsson
Journal of Clinical Endocrinology & Metabolism - 2005 -
Gene expression profiling of the rat hippocampus one month after focal cerebral ischemia followed by enriched
environment.
Annica Rönnbäck, Per Dahlqvist, Per-Arne Svensson, Margareta Jernås, Björn Carlsson, Lena M S Carlsson, Tommy Olsson
Neuroscience Letters - 2005 -
Methodological studies of multiple reference genes as endogenous controls in vascular gene expression
studies
Roya Doroudi, Maria Andersson, Per-Arne Svensson, Mikael Ekman, Sverker Jern, Lena Karlsson
Endothelium - 2005 -
Differential global gene expression response patterns of human endothelium exposed to shear stress and intraluminal
pressure
Maria Andersson, Lena Karlsson, Per-Arne Svensson, Erik Ulfhammer, Mikael Ekman, Margareta Jernås, Lena M S Carlsson, Sverker Jern
J Vasc Res - 2005 -
Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight
loss.
Raffaella Cancello, Corneliu Henega, Nathalie Viguerie, Soraya Taleb, Christine Poitou, Christine Rouault, Muriel Coupaye, Veronique Pelloux, Danielle Hugol, Jean-Luc Bouillot, Anne Bouloumié, Giorgio Barbatelli, Saverio Cinti, Per-Arne Svensson, Gregory S. Barsh, Jean-Daniel Zucker, Arnaud Basdevant, Dominique Langin, Karine Clément
Diabetes - 2005 -
Progesterone-receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in
vitro
Emilia Rung, P. Anders Friberg, Linus Ruijin Shao, D. G. Joakim Larsson, Eva Ch. Nielsen, Per-Arne Svensson, Björn Carlsson, Lena M S Carlsson, Håkan Billig
Biology of reproduction - 2005 -
Identification of genes predominantly expressed in human
macrophages
Per-Arne Svensson, Daniel Hägg, Margareta Jernås, Mikael C.O. Englund, Lillemor Mattsson Hulten, Bertil G. Ohlsson, Johannes Hulthe, Olov Wiklund, Björn Carlsson, Björn Fagerberg, Lena M.S. Carlsson
Atherosclerosis - 2004 -
Hypoxia increases LDL oxidation and expression of 15-lipoxygenase-2 in human
macrophages
Ellen Knutsen Rydberg, Alexandra Krettek, Christina Ullström, Karin Ekström, Per-Arne Svensson, Lena M S Carlsson, Ann-Christine Jönsson-Rylander, G.I Hansson, W. McPheat, Olov Wiklund, Bertil Ohlsson, Lillemor Mattsson Hultén
Arterioscler Thromb Vasc Biol - 2004 -
Gene profiling reveals increased expression of uteroglobin and other anti-inflammatory genes in glucocorticoid-treated nasal
polyps.
Mikael Benson, Lena M S Carlsson, Mikael Adner, Margareta Jernås, Mats Rudemo, Anders Sjögren, Per-Arne Svensson, Rolf Uddman, Lars Olaf Cardell
Journal of Allergy and Clinical Immunology - 2004 -
DNA microarray analysis of chromosomal susceptibility regions to identify candidate genes for allergic disease: a pilot
study.
Mikael Benson, Per-Arne Svensson, Mikael Adner, Helena Carén, Björn Carlsson, Lena M S Carlsson, Tommy Martinsson, Mats Rudemo, Lars Olaf Cardell
Acta Oto-Laryngologica - 2004 -
Interaction of scavenger receptor class B type I with peroxisomal targeting receptor
Pex5p.
Magnus S.C. Johnson, Jenny M Johansson, Per-Arne Svensson, Maria A I Åberg, Peter S Eriksson, Lena M S Carlsson, Björn Carlsson
Biochemical and biophysical research communications - 2003 -
Copper induces the expression of cholesterogenic genes in human
macrophages.
Per-Arne Svensson, Mikael C. O. Englund, Emilia Markström, Bertil Ohlsson, Margareta Jernås, Håkan Billig, Jarl S Torgerson, Olov Wiklund, Lena M S Carlsson, Björn Carlsson
Atherosclerosis - 2003 -
Expression of scavenger receptor class B type I in gallbladder columnar
epithelium.
Magnus S.C. Johnson, Per-Arne Svensson, Jan Borén, Håkan Billig, Lena M S Carlsson, Björn Carlsson
Journal of gastroenterology and hepatology - 2002 -
DNA microarray analysis of transforming growth factor-β and related transcripts in nasal biopsies from patients with allergic
rhinitis
Mikael Benson, Björn Carlsson, Lena M S Carlsson, Petter Mostad, Per-Arne Svensson, Lars-Olaf Cardell
Cytokine - 2002 -
DNA microarrays to study gene expression in allergic
airways.
Mikael Benson, Per-Arne Svensson, B Carlsson, Margareta Jernås, J Reinholdt, L O Cardell, Lena M S Carlsson
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 2002 -
Studies on scavenger receptor class B type I and genes implicated in foam cell
formation
Per-Arne Svensson
2001 -
Isolation of differentially expressed aldose reductase in ovaries after estrogen withdrawal from hypophysectomized diethylstilbestrol treated rats: increased expression during
apoptosis.
B Svanberg, C Ling, Per-Arne Svensson, M Johnson, B Carlsson, H Billig
Molecular and cellular endocrinology - 2000 -
Scavenger receptor class B type I in the rat ovary: possible role in high density lipoprotein cholesterol uptake and in the recognition of apoptotic granulosa
cells.
Per-Arne Svensson, M S Johnson, C Ling, L M Carlsson, H Billig, B Carlsson
Endocrinology - 1999 -
Characterization and chromosomal localization of rat scavenger receptor class B type I, a high density lipoprotein receptor with a putative leucine zipper domain and peroxisomal targeting
sequence.
M S Johnson, Per-Arne Svensson, K Helou, H Billig, G Levan, L M Carlsson, B Carlsson
Endocrinology - 1998 -
Cloning of two novel growth hormone transcripts expressed in human
placenta.
C L Boguszewski, Per-Arne Svensson, T Jansson, R Clark, L M Carlsson, B Carlsson
The Journal of clinical endocrinology and metabolism - 1998